Which of the following are the best indicators of poor storage?

The best indicators of poor storage are related to the stability and efficacy of certain antibiotics under varying conditions. Penicillin and methicillin are classic examples of antibiotics that can degrade or lose their potency when not stored properly, particularly when exposed to light, moisture, or extreme temperatures.

Penicillin is known to be sensitive to degradation, and its effectiveness can diminish significantly if it is not stored in accordance with recommended guidelines. Similarly, methicillin can also be unstable in less than ideal storage conditions, resulting in a loss of potency. Therefore, their ability to indicate poor storage practices stems from their known sensitivities and the consequences of improper handling.

By selecting penicillin and methicillin, you identify two antibiotics whose degradation can directly signal issues with storage conditions, thus making them reliable indicators in this context. Their properties help in assessing whether storage practices are being adhered to, which is crucial for maintaining the integrity of pharmaceuticals.