Infections with which microorganism may result in the presence of "clue cells"?

The presence of "clue cells" is primarily associated with infections caused by Gardnerella vaginalis. Clue cells are vaginal epithelial cells that become coated with bacteria, creating a stippled appearance under the microscope. This phenomenon is a characteristic finding in bacterial vaginosis, a condition linked to an overgrowth of various bacteria, with Gardnerella vaginalis being one of the key contributors to this imbalance.

In contrast, the other microorganisms listed do not lead to the formation of clue cells. Campylobacter coli is known for causing gastrointestinal infections, primarily leading to diarrhea and abdominal pain. Legionella pneumophila is associated with pneumonia and does not influence vaginal flora to the extent that would result in clue cell formation. Brucella canis, similar to the others, is primarily linked to zoonotic infections and does not have a role in altering vaginal epithelial cells in a way that would produce clue cells. Thus, Gardnerella vaginalis stands out as the organism specifically related to the clinical manifestation of clue cells.